banner

Model-based hybrid variational level set method applied to lung cancer detection

Wang Jing, Liew Siau Chuin, Azian Abd Aziz

Abstract


The precise segmentation of lung lesions in computed tomography (CT) scans holds paramount importance for lung cancer research, offering invaluable information for clinical diagnosis and treatment. Nevertheless, achieving efficient detection and segmentation with acceptable accuracy proves to be challenging due to the heterogeneity of lung nodules. This paper presents a novel model-based hybrid variational level set method (VLSM) tailored for lung cancer detection. Initially, the VLSM introduces a scale-adaptive fast level-set image segmentation algorithm to address the inefficiency of low gray scale image segmentation. This algorithm simplifies the (Local Intensity Clustering) LIC model and devises a new energy functional based on the region-based pressure function. The improved multi-scale mean filter approximates the image’s offset field, effectively reducing gray-scale inhomogeneity and eliminating the influence of scale parameter selection on segmentation. Experimental results demonstrate that the proposed VLSM algorithm accurately segments images with both gray-scale inhomogeneity and noise, showcasing robustness against various noise types. This enhanced algorithm proves advantageous for addressing real-world image segmentation problems and nodules detection challenges.


Keywords


lung cancer; medical image; computed tomography

Full Text:

PDF

References


1. Sung H, Ferlay J, Siegel RL, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA: a Cancer Journal for Clinician 2021; 71(3): 209–249. doi: 10.3322/caac.21660

2. Duan H, Hu JL, Chen ZH, et al. Assessment of circulating tumor DNA in cerebrospinal fluid by whole exome sequencing to detect genomic alterations of glioblastoma. Chinese Medical Journal 2020; 133(12): 1415–1421. doi: 10.1097/CM9.0000000000000843

3. National Lung Screening Trial Research Team. Reduced lung-cancer mortality with low-dose computed tomographic screening. The New England Journal of Medicine 2011; 365(5): 395–409. doi: 10.1056/NEJMoa1102873

4. Schabath MB, Cote ML. Cancer progress and priorities: Lung cancer. Cancer Epidemiology, Biomarkers & Prevention 2019; 28(10): 1563–1579. doi: 10.1158/1055-9965.EPI-19-0221

5. Wu F, Wang L, Zhou C. Lung cancer in China: Current and prospect. Current opinion in oncology 2021; 33(1): 40–46. doi: 10.1097/CCO.0000000000000703

6. Huang M, Wang W. Application observation of expression of serum cytokeratin 19 fragment, neuron-specific enolase, and squamous cell carcinoma antigen in the differential diagnosis of early lung cancer and pulmonary tuberculosis. Chinese Journal of Clinicians 2021; 49(8): 916–919. doi: 10.3969/j.issn.2095-8552.2021.08.011

7. He H, Hu C, Zhong T, et al. The clinical value of combined detection of CEA, NSE, CYFRA21-1, and ProGRP in the diagnosis of lung cancer. Experimental and Laboratory Medicine 2019; 37(3): 435–437. doi: 10.3969/j.issn.1674-1129.2019.03.028

8. Bruzzi JF, Munden RF. PET/CT imaging of lung cancer. Journal of Thoracic Imaging 2006; 21(2): 123–136. doi: 10.1097/00005382-200605000-00004

9. Munden RF, Swisher SS, Stevens CW, Stewart DJ. Imaging of the patient with non-small cell lung cancer. Radiology 2005; 237(3): 803–818. doi: 10.1148/radiol.2373040966

10. Birim Ö, Kappetein AP, Stijnen T, Bogers AJJC. Meta-analysis of positron emission tomographic and computed tomographic imaging in detecting mediastinal lymph node metastases in nonsmall cell lung cancer. The Annals of Thoracic Surgery 2005; 79(1): 375–382. doi: 10.1016/j.athoracsur.2004.06.041

11. Neal RD, Barham A, Bongard E, et al. Immediate chest X-ray for patients at risk of lung cancer presenting in primary care: randomised controlled feasibility trial. British Journal of Cancer 2017; 116(3): 293–302. doi: 10.1038/bjc.2016.414

12. De González AB, Darby S. Risk of cancer from diagnostic X-rays: Estimates for the UK and 14 other countries. The Lancet 2004; 363(9406): 345–351. doi: 10.1016/S0140-6736(04)15433-0

13. Blanchon T, Bréchot J-M, Grenier P A, et al., Baseline results of the Depiscan study: A French randomized pilot trial of lung cancer screening comparing low dose CT scan (LDCT) and chest X-ray (CXR). Lung Cancer 2007; 58(1): 50–58. doi: 10.1016/j.lungcan.2007.05.009

14. Sawka A, Crawford A, Peh CA, Nguyen P. Tracheobronchial calcification on bronchoscopy in a patient with end stage renal failure: An unusual cause of chronic cough. Respirology Case Reports 2019; 7(7): e00456. doi: 10.1002/rcr2.456

15. Ambrosini V, Nicolini S, Caroli P, et al. PET/CT imaging in different types of lung cancer: An overview. European Journal of Radiology 2012; 81(5): 988–1001. doi: 10.1016/j.ejrad.2011.03.020

16. Hochhegger B, Marchiori E, Sedlaczek O, et al. MRI in lung cancer: A pictorial essay. The British Journal of Radiology 2011; 84(1003): 661–668. doi: 10.1259/bjr/24661484

17. Wu NY, Cheng HC, Ko JS, et al. Magnetic resonance imaging for lung cancer detection: experience in a population of more than 10,000 healthy individuals. BMC Cancer 2011; 11: 242. doi: 10.1186/1471-2407-11-242

18. Ohno Y, Koyama H, Lee HY, et al. Magnetic resonance imaging (MRI) and positron emission tomography (PET)/MRI for lung cancer staging. Journal of Thoracic Imaging 2016; 31(4): 215–227. doi: 10.1097/RTI.0000000000000210

19. Chu GCW, Lazare K, Sullivan F. Serum and blood based biomarkers for lung cancer screening: a systematic review. BMC Cancer 2018; 18(1): 181. doi: 10.1186/s12885-018-4024-3

20. Wu Y, Ma W, Gong M, et al. Novel fuzzy active contour model with kernel metric for image segmentation. Applied Soft Computing 2015; 34: 301–311. doi: 10.1016/j.asoc.2015.04.058

21. Li C, Huang R, Ding Z, et al. A level set method for image segmentation in the presence of intensity inhomogeneities with application to MRI. IEEE transactions on image processing 2011; 20(7): 2007–2016. doi: 10.1109/TIP.2011.2146190

22. Liu L, Zhang Q, Wu M, et al. Adaptive segmentation of magnetic resonance images with intensity inhomogeneity using level set method. Magnetic resonance imaging 2013; 31(4): 567–574. doi: 10.1016/j.mri.2012.10.010

23. Liu Y, He C, Wu Y. Variational model with kernel metric-based data term for noisy image segmentation. Digital Signal Processing 2018; 78: 42–55. doi: 10.1016/j.dsp.2018.01.017




DOI: https://doi.org/10.32629/jai.v7i5.921

Refbacks

  • There are currently no refbacks.


Copyright (c) 2024 Wang Jing, Liew Siau Chuin, Azian Abd Aziz

License URL: https://creativecommons.org/licenses/by-nc/4.0/