banner

An integrated system for breast cancer diagnosis using convolution neural network and attention mechanism

Deepti Sharma, Rajneesh Kumar, Anurag Jian

Abstract


In most malignancies, breast cancer is fatal, accounting for approximately 500,000 annual deaths. The subtype of breast cancer known as Invasive Ductal Carcinoma (IDC) is surprisingly common. Pathologists commonly focus on IDC-containing regions when trying to determine if a patient has breast cancer. Although extremely fatal, survival rates and expected lifespans improve dramatically with prompt diagnosis and treatment. The treatment strategy also varies based on the breast cancer patient’s stage. In this research, we use a classification method for a publically available dataset of breast histopathology images obtained from the Kaggle. The IDC regions of the images in this dataset have been restricted for easy retrieval. The breast cancer IDC data set contains 277,524 records, of which 78,786 are positive. The 277,524 images were classified using an IDC breast cancer dataset, with 78,786 positive IDC and 198,738 negative IDC, respectively. The authors introduce a new architecture of deep convolutional neural networks and attention mechanism for classification. The model achieves state-of-the-art levels of accuracy for IDC identification, setting a new benchmark for future studies.


Keywords


breast cancer; histopathology; convolutional neural networks; deep learning

Full Text:

PDF

References


1. Mansour RF. A robust deep neural network based breast cancer detection and classification. International Journal of Computational Intelligence and Applications 2020; 19(1): 2050007. doi: 10.1142/s1469026820500078

2. Yadavendra, Chand S. A comparative study of breast cancer tumor classification by classical machine learning methods and deep learning method. Machine Vision and Applications 2020; 31(6): 46. doi: 10.1007/s00138-020-01094-1

3. Le Thien MA, Redjdal A, Bouaud J, Séroussi B. Using machine learning on imbalanced guideline compliance data to optimise multidisciplinary tumour board decision making for the management of breast cancer patients. Studies in Health Technology and Informatics 2022; 290; 787–788. doi: 10.3233/SHTI220186

4. Khari BA, Akhtar N, Asad R, et al. A novel deep learning model for breast cancer classification using histopathology images. Journal of Jilin University 2023; 42(3): 771–778. doi: 10.17605/OSF.IO/WNQ34

5. He T, Puppala M, Ezeana CF, et al. A deep learning-based decision support tool for precision risk assessment of breast cancer. JCO Clinical Cancer Informatics 2019; (3): 1–12. doi: 10.1200/cci.18.00121

6. Bhise S, Gadekar S, Gaur AS, et al. Breast cancer detection using machine learning techniques. International Journal of Engineering Research & Technology 2021; 10(7). doi: 10.17577/IJERTV10IS070064

7. Shabnaz S, Ahmed MU, Islam MdS, et al. Breast cancer risk in relation to TP53 codon 72 and CDH1 gene polymorphisms in the Bangladeshi women. Tumor Biology 2016; 37(6): 7229–7237. doi: 10.1007/s13277-015-4612-7

8. Salama WM, Aly MH. Deep learning in mammography images segmentation and classification: Automated CNN approach. Alexandria Engineering Journal 2021; 60(5): 4701–4709. doi: 10.1016/j.aej.2021.03.048

9. Gravina M, Marrone S, Sansone M, Sansone C. DAE-CNN: Exploiting and disentangling contrast agent effects for breast lesions classification in DCE-MRI. Pattern Recognition Letters 2021; 145: 67–73. doi: 10.1016/j.patrec.2021.01.023

10. Ukwuoma CC, Hossain MA, Jackson JK, et al. Multi-classification of breast cancer lesions in histopathological images using DEEP_Pachi: Multiple self-attention head. Diagnostics 2022; 12(5): 1152. doi: 10.3390/diagnostics12051152

11. Yala A, Mikhael PG, Strand F, et al. Toward robust mammography-based models for breast cancer risk. Science Translational Medicine 2021;13(578): eaba4373. doi: 10.1126/scitranslmed.aba4373

12. Ramanath TT, Hossen MJ, Sayeed MS. Blockchain integrated multi-agent system for breast cancer diagnosis. Indonesian Journal of Electrical Engineering and Computer Science 2022; 26(2): 998. doi: 10.11591/ijeecs.v26.i2.pp998-1008

13. Houssein EH, Emam MM, Ali AA. An optimised deep learning architecture for breast cancer diagnosis based on improved marine predators algorithm. Neural Computing and Applications 2022; 34(20): 18015–18033. doi: 10.1007/s00521-022-07445-5

14. Narayanan BN, Krishnaraja V, Ali R. Convolutional neural network for classification of histopathology images for breast cancer detection. In: Proceedings of the 2019 IEEE National Aerospace and Electronics Conference (NAECON); 15–19 July 2019; Dayton, OH, USA. pp. 291–295.

15. Zhou X, Tang C, Huang P, et al. LPCANet: Classification of laryngeal cancer histopathological images using a CNN with position attention and channel attention mechanisms. Interdisciplinary Sciences: Computational Life Sciences 2021; 13(4): 666–682. doi: 10.1007/s12539-021-00452-5

16. Ambika M, Raghuraman G, SaiRamesh L. Enhanced decision support system to predict and prevent hypertension using computational intelligence techniques. Soft Computing 2020; 24(17): 13293–13304. doi: 10.1007/s00500-020-04743-9

17. Zhou P, Cao Y, Li M, et al. HCCANet: Histopathological image grading of colorectal cancer using CNN based on multichannel fusion attention mechanism. Scientific Reports 2022;12(1): 15103. doi:10.1038/s41598-022-18879-1

18. Abdelrahman L, Al Ghamdi M, Collado-Mesa F, Abdel-Mottaleb M. Convolutional neural networks for breast cancer detection in mammography: A survey. Computers in Biology and Medicine 2021; 131: 104248. doi: 10.1016/j.compbiomed.2021.104248

19. Xu X, An M, Zhang J, et al. A high-precision classification method of mammary cancer based on improved DenseNet driven by an attention mechanism. Computational and Mathematical Methods in Medicine 2022; 2022: 8585036. doi: 10.1155/2022/8585036

20. Xu B, Liu J, Hou X, et al. Attention by selection: A deep selective attention approach to breast cancer classification. IEEE Transactions on Medical Imaging 2019; 39(6): 1930–1941. doi: 10.1109/tmi.2019.2962013

21. Roy SD, Das S, Kar D, et al. Computer aided breast cancer detection using ensembling of texture and statistical image features. Sensors 2021; 21(11): 3628. doi: 10.3390/s21113628

22. Kirelli Y, Arslankaya S, Koçer HB, Harmantepe T. CNN-based deep learning method for predicting the disease response to the Neoadjuvant Chemotherapy (NAC) treatment in breast cancer. Heliyon 2023; 9(6): e16812. doi: 10.1016/j.heliyon.2023.e16812

23. Wang X, Ahmad I, Javeed D, et al. Intelligent hybrid deep learning model for breast cancer detection. Electronics 2022; 11(17): 2767. doi: 10.3390/electronics11172767

24. Voon W, Hum YC, Tee YK, et al. Performance analysis of seven convolutional neural networks (CNNs) with transfer learning for invasive ductal carcinoma (IDC) grading in breast histopathological images. Scientific Reports 2022; 12(1): 19200. doi: 10.1038/s41598-022-21848-3

25. Toğaçar M, Özkurt KB, Ergen B, Cömert Z. BreastNet: A novel convolutional neural network model through histopathological images for the diagnosis of breast cancer. Physica A: Statistical Mechanics and its Applications 2020; 545: 123592. doi: 10.1016/j.physa.2019.123592

26. Chaudhury S, Krishna AN, Gupta S, et al. Effective image processing and segmentation-based machine learning techniques for diagnosis of breast cancer. Computational and Mathematical Methods in Medicine 2022; 2022: 6841334. doi: 10.1155/2022/6841334

27. Yao H, Zhang X, Zhou X, Liu S. Parallel structure deep neural network using CNN and RNN with an attention mechanism for breast cancer histology image classification. Cancers 2019; 11(12): 1901. doi: 10.3390/cancers11121901

28. Aldhyani THH, Khan MA, Almaiah MA, et al. A secure Internet of medical things framework for breast cancer detection in sustainable smart cities. Electronics 2023; 12(4): 858. doi: 10.3390/electronics12040858

29. Zhang Z, Li Z. Evaluation methods for breast cancer prediction in machine learning field. In: Proceedings of the 2022 International Conference on Science and Technology Ethics and Human Future (STEHF 2022); 12–14 May 2023.

30. Mooney P. Breast histopathology images. Available online: https://www.kaggle.com/paultimothymooney/breast-histopathology-images (accessed on 13 November 2023).

31. Singh S, Kumar R. Breast cancer detection from histopathology images with deep inception and residual blocks. Multimedia Tools and Applications 2022; 81(4): 5849–5865. doi: 10.1007/s11042-021-11775-2

32. Mahmud MI, Mamun M, Abdelgawad A. A deep analysis of transfer learning based breast cancer detection using histopathology images. In: Proceedings of the 2023 10th International Conference on Signal Processing and Integrated Networks (SPIN); 23–24 March 2023; Noida, India. pp. 198–204.

33. Roy SD, Das S, Kar D, Schwenker F, Sarkar R. Computer aided breast cancer detection using ensembling of texture and statistical image features. Sensors 2021; 21(11): 3628.

34. Li H, Liu Z, Yuan L, et al. Radionuclide-based imaging of breast cancer: state of the art. Cancers 2021; 13(21): 5459.

35. Agarwal P, Yadav A, Mathur P. Breast cancer prediction on breakhis dataset using deep CNN and transfer learning model. In: Data Engineering for Smart Systems: Proceedings of SSIC 2021. Springer Singapore; 2022. pp. 77–88.

36. Wang X, Ahmad I, Javeed D, et al. Intelligent Hybrid Deep Learning Model for Breast Cancer Detection. Electronics 2022; 11(17): 2767.

37. Mahmud MI, Mamun M, Abdelgawad A. A Deep Analysis of Transfer Learning Based Breast Cancer Detection Using Histopathology Images. In: Proceedings of the 2023 10th International Conference on Signal Processing and Integrated Networks (SPIN). IEEE. pp. 198–204.

38. Chaudhury S, Sau K, Khan MA, Shabaz M. Deep transfer learning for IDC breast cancer detection using fast AI technique and Sqeezenet architecture. Math Biosci Eng 2023; 20: 10404–10427.




DOI: https://doi.org/10.32629/jai.v7i2.943

Refbacks

  • There are currently no refbacks.


Copyright (c) 2023 Deepti Sharma, Rajneesh Kumar, Anurag Jain

License URL: https://creativecommons.org/licenses/by-nc/4.0/